Clonazepam/Pase – Pediatric Drops is used in the treatment of anxiety disorder and Epilepsy/Seizures.
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Clonazepam is a medication utilized to manage or prevent various seizure types and fits, which result from brain electrical disturbances. It's also used for treating panic attacks and sleep disorders. The mechanism involves triggering the release of gamma-amino-butyric acid (GABA), a chemical that regulates brain electrical activity.
Possible side effects encompass fatigue, dizziness, depression, memory issues, and confusion. While some of these effects may not necessitate medical attention, promptly inform your doctor about any new or deteriorating symptoms like breathing difficulties, extreme drowsiness, hallucinations, altered behavior, or suicidal thoughts.
Clonazepam can be taken with or without food, adhering strictly to your doctor's instructions to minimize addiction risks. Individuals with kidney or liver problems should avoid this medicine as it could exacerbate their condition. It's not advisable during pregnancy or breastfeeding unless the benefits clearly outweigh the risks. Inform your doctor if you're pregnant or nursing.
Due to potential dizziness, refrain from tasks needing focus, like driving. Alcohol should be avoided while taking Clonazepam, as it can intensify dizziness and drowsiness.
Consumption of alcohol should be avoided while you are taking Clonazepam as it can cause drowsiness and even difficulty in breathing.
Clonazepam is not recommended for use in pregnancy as it may negatively affect the growth of your unborn baby. Hence, inform your doctor if you are pregnant or planning pregnancy before taking this medicine. He/she may prescribe this medicine only if the benefits outweigh the risk.
Clonazepam is not recommended for use in breastfeeding women as this medicine can pass into the breast milk in a small amount. Take this medicine while breastfeeding only if your doctor prescribes it.
Activities that require high mental alertness (such as driving and operating heavy machines) should be avoided.
Pase – Pediatric drops should be used with caution in patients with kidney disease. A dose adjustment of Pase Drop may be needed. Please consult your doctor. The use of Pase Drop can cause excessive sleepiness in patients with end-stage kidney disease.
ase Drop should be used with caution in patients with liver disease. Dose adjustment of Pase Drop may be needed. Please consult your doctor.
Clonazepam works by stimulating the release of a chemical [gamma-amino-butyric-acid (GABA)] that calms the abnormal electrical activity in the brain.
It is indicated for the treatment of panic disorder, with or without agoraphobia. Panic disorder is characterized by the occurrence of unexpected panic attacks and associated concern about having additional attacks, and worry about the implications or consequences of the attacks.
It is also indicated alone or as an adjunct in the treatment of the Lennox-Gastaut Syndrome (petit mal variant), akinetic and myoclonic seizures. It may be indicated in patients with absence seizures (petit mal) who have failed to respond to succinimides.
The effectiveness of Clonazepam in long-term use, that is, for more than 9 weeks, has not been systematically studied in controlled clinical trials. The physician who elects to use Clonazepam for extended periods should periodically reevaluate the long-term usefulness of the drug for the individual patient.
Clonazepam exhibits pharmacological characteristics common to benzodiazepines, encompassing anticonvulsant, sedative, muscle-relaxant, and anxiolytic effects. The fundamental actions of benzodiazepines are facilitated by enhancing GABAergic neurotransmission at inhibitory synapses. In the presence of benzodiazepines, GABA receptor affinity for the neurotransmitter is augmented through positive allosteric modulation, resulting in increased GABA activity on postsynaptic transmembrane chloride ion flow. Additionally, animal data suggests an impact of clonazepam on serotonin. Animal studies and human electroencephalographic investigations indicate that clonazepam rapidly suppresses various forms of paroxysmal activity, including spike and wave discharges in absence seizures (petit mal), slow spike-wave, generalized spike-wave, spikes with transient or other patterns, as well as sporadic spikes and waves. Generalized EEG abnormalities are also commonly observed.
Adults:
For seizure disorders, the initial dose should not exceed 1.5 mg/day, divided into three doses.
Dosage can be increased by 0.5 to 1 mg every 3 days until seizures are controlled or side effects prevent further increase.
The maintenance dose should be personalized based on response.
Maximum daily dose: 20 mg.
For panic disorder, start with 0.25 mg twice daily.
After 3 days, most patients can be increased to the target dose of 1 mg/day.
Pediatric Patients:
Pediatric Use:
Geriatric Use:
Renal Impairment:
Hepatic Impairment:
Pregnancy:
Nursing Mothers:
When used in patients in whom several different types of seizure disorders coexist, Clonazepam may increase the incidence or precipitate the onset of generalized tonic-clonic seizures. This may require the addition of appropriate anticonvulsants or an increase in their dosages. The concomitant use of valproic acid and Clonazepam may produce absence status.
Store Pase – Pediatric Drops in dry conditions at room temperature. Keep them away from humid conditions and direct sunlight. Dispose of the packaging carefully after using these Pase – Pediatric Drops. Do not use Pase – Pediatric Drops if the package has been opened. Keep Pase – Pediatric Drops away from children and pets
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